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Benadryl (diphenhydramine)

Benadryl IV Therapy – Fast-Acting Antihistamine Support

Benadryl (Diphenhydramine) IV therapy is a powerful antihistamine used to treat a range of allergic reactions, inflammation-related discomfort, and pre-medication protocols in IV vitamin therapy. Administered intravenously, Benadryl offers faster relief than oral tablets, especially in acute or severe allergic response scenarios.

What Is Benadryl IV Therapy Used For?

Benadryl IV (Diphenhydramine Hydrochloride) is commonly used in clinical and wellness protocols for:

  • Allergic reactions (hives, rashes, swelling)
  • Seasonal allergies or environmental exposure
  • Nausea or dizziness caused by histamine reactions
  • Pre-treatment to prevent reactions during IV infusions (e.g., high-dose vitamin C or glutathione)
  • Reducing inflammation or immune overreaction

How Benadryl IV Works

When administered via IV, Benadryl quickly enters the bloodstream to block histamine receptors. This reduces allergy-related symptoms such as itching, swelling, and nasal congestion within minutes. It's especially effective for patients who need rapid relief or are unable to tolerate oral antihistamines.

Clinical Considerations & Safety

Benadryl IV should only be administered by a licensed medical professional. The dosage and infusion rate must be determined based on patient weight, age, and condition. It is not recommended for individuals with certain conditions such as glaucoma, enlarged prostate, or those taking CNS depressants.

Standard Dosing Guidelines (General Reference)

  • Adults: 10–50 mg IV every 4–6 hours as needed
  • Maximum single dose: 50 mg
  • Infusion Rate: Should be administered slowly over 1–2 minutes

Note: All doses must be guided by a provider’s instruction based on clinical indication.

When to Consider Benadryl IV Therapy

If you suffer from severe seasonal allergies, histamine intolerance, or plan to undergo IV therapies that may trigger allergic responses, Benadryl IV may be a beneficial support option. Our licensed mobile nurses will assess your symptoms and administer Benadryl with care and caution.

Book Your Mobile IV Benadryl Treatment

Our team at In Home Infusion delivers expert care straight to your door. Whether you’re managing chronic allergies or preparing for another IV infusion, we’ll make sure you’re supported with safe, effective antihistamine treatment.

📞 Call or Text to Schedule: 442-216-0948

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Therapy Menu

Our specialty mixtures

Our bags are not premixed allowing you to customize your therapies

Hydration

Target: Dehydration, mild nausea

Intravenous (IV)

  • IV Fluid – 1L 0.9% NaCl IV, 1L Lactated Ringers IV, or 1L Intralipid
  • Customize your therapy from solution base

Awake

Target: Dehydration, fatigue, jet lag, sports recovery

Intravenous (IV)

  • IV Fluid – 1L 0.9% NaCl IV
  • Vitamin B complex – 1mL IV in bag

Intramuscular (IM)

  • Vitamin B12 – 1,000mcg (1mg) IM

Slow IV Push

  • Taurine – 50mg IV push

Hangover

Target: Dehydration, nausea, migraine, vomiting, fatigue

Intravenous (IV)

  • IV Fluid – 1L Lactated Ringer (preferred)
  • Vitamin B complex – 1mL IV in bag
  • Magnesium – 200 mg in bag

Slow IV Push

  • Glutathione – 200mg IV push
  • Zofran – 4mg IV push
  • Toradol – 15-30mg IV push

Cold & Flu

Target: Dehydration, aches, pains, cough, congestion, fatigue, flu like symptoms

Intravenous (IV)

  • IV Fluid – 1L Lactated Ringer (preferred)
  • Vitamin B complex – 1mL IV in bag
  • Zinc – 2.5 mg IV in bag

Intramuscular (IM)

  • Vitamin B12 – 1,000mcg (1mg) IM

Slow IV Push

  • Glutathione – 200mg IV push
  • +/- Toradol – 15-30mg IV push

Immunity

Target: Dehydration, immunity, fatigue

Intravenous (IV)

  • IV Fluid – 1,000mL 0.9% NaCl (preferred)
  • Vitamin B complex – 1mL IV in bag
  • Vitamin C – 1,000 mg IV in bag
  • Zinc – 2.5 mg IV in bag

Intramuscular (IM)

  • Vitamin B12 – 1,000mcg (1mg) IM

Slow IV Push

  • Glutathione – 200mg IV push

Lipo-Mino Complex

Target: Dehydration, weight loss, energy, appetite regulation

Intravenous (IV)

  • IV Fluid – 1L 0.9% NaCl IV
  • Vitamin B complex – 1mL IV in bag

Intramuscular (IM)

  • LIPO-Mino – 1mL

Slow IV Push

  • Glutathione – 200mg IV push
  • Taurine – 50mg IV push

Food Poisoning & Stomach Flu

Target: Dehydration, nausea, vomiting, stomach pain

Intravenous (IV)

  • IV Fluid – 1L 0.9% NaCl IV
  • Vitamin B complex – 1mL IV in bag
  • Zinc – 2.5 mg IV in bag

Intramuscular (IM)

  • Vitamin B12 – 1,000mcg (1mg) IM

Slow IV Push

  • Glutathione – 200mg IV push
  • Zofran – 4mg IV push

Pepcid – 20mg IV push (dilute in 10mL)

Migraine

Target: Dehydration, migraine or headache

Intravenous (IV)

  • IV Fluid – 1L 0.9% Lactated Ringer (preferred)
  • Vitamin B complex – 1mL IV in bag
  • Magnesium – 200 mg IV in bag
  • Zinc – 2.5 mg IV in bag

Intramuscular (IM)

  • Vitamin B12 – 1,000mcg (1mg)

Slow IV Push

  • Zofran – 4mg IV push
  • Toradol – 15-30mg IV push
  • Benadryl– 50mg IV push

SHE

Target: Dehydration, menstrual cramps (dysmenorrhea)

Intravenous (IV)

  • IV Fluid – 1L 0.9% Lactated Ringer (preferred)
  • Vitamin B complex – 1mL IV in bag
  • Magnesium – 200 mg IV in bag
  • Zinc – 2.5 mg IV in bag

Intramuscular (IM)

  • Vitamin B12 – 1,000mcg (1mg)

Slow IV Push

  • Zofran – 4mg IV push
  • Toradol – 15-30mg IV push
  • Benadryl– 50mg IV push

Myers Cocktail

Target: Dehydration, wellness, fatigue, immunity

Intravenous (IV)

  • IV Fluid – 1L 0.9% NaCl (preferred)
  • Vitamin B complex – 1mL IV in bag
  • Vitamin C – 1,000mg IV in bag
  • Magnesium – 200mg IV in bag

Intramuscular (IM)

Vitamin B12 – 1,000mcg (1mg) IM

Superstar

Target: Dehydration, fatigue, immunity, acute symptoms, nausea, recovery, detox, and more

Intravenous (IV)

  • IV Fluid – 1L 0.9% NaCl IV
  • Vitamin B complex – 1mL IV in bag
  • Magnesium – 200mg IV in bag
  • Vitamin C – 2,000mg IV in bag
  • Zinc – 2.5mg IV in bag

Intramuscular (IM)

  • Vitamin B12 – 1,000mcg (1mg) IM

Slow IV Push:

  • Glutathione – 400mg IV push
  • Taurine – 50 mg IV push
  • If appropriate per symptom assessment or requested (INCLUDED in package charge):
  • Medicines
  • May substitute Lipo-Mino for B12 and B complex

Ultimate Superstar

Target: Dehydration, fatigue, immunity, acute symptoms, nausea, recovery, detox, and more at a max dose

Intravenous (IV)

  • IV Fluid – 1L 0.9% NaCl IV
  • Vitamin B complex – 1 mL IV in bag
  • Magnesium – 400mg IV in bag
  • Vitamin C – 10,000mg IV in bag
  • Zinc – 2.5mg IV in bag

Intramuscular (IM)

  • Vitamin B12 – 1,000mcg (1mg) IM

Slow IV Push:

  • Glutathione – 1,000mg IV push
  • Taurine – 100mg IV push
  • If appropriate per symptom assessment or requested (INCLUDED in package charge):
  • Medicines
  • May substitute Lipo-Mino for B12 and B complex

NAD+

Target: Dehydration, fatigue, immunity, acute symptoms, nausea, recovery, detox, and more

Intravenous (IV)

  • IV Fluid – 500mL 0.9% NaCl IV
  • NAD+: 500mg IV in bag
  • Additional NAD+: IV in bag ($1.50/mg additional
    charge)

NAD+ Superstar

Target: Dehydration, fatigue, immunity, acute symptoms, nausea, recovery, detox, anti-aging, accelerated cellular regeneration, and more

Intravenous (IV)

  • IV Fluid – 1L 0.9% NaCl IV
  • Vitamin B complex – 1mL IV in bag
  • Magnesium – 200mg IV in bag
  • Vitamin C – 2,000mg IV in bag
  • Zinc – 2.5mg IV in bag

Intramuscular (IM)

  • Vitamin B12 – 1,000mcg (1mg) IM

Slow IV Push:

  • Glutathione – 400mg IV push
  • Taurine – 50 mg IV push
  • If appropriate per symptom assessment or requested (INCLUDED in package charge):
  • Medicines
  • May substitute Lipo-Mino for B12 and B complex

Option 1: Calendar Date Request

Select any service if unsure, we can always edit your request later, the nurse comes fully equipped for any scenario. Your request on calendar will be pending until a nurse confirms. We will keep you updated via SMS on this process. After confirmation your nurse will reach out for introduction, consultation, and to provide an ETA. Reserve all medical questions for your nurse when paired. Please include any important medical history in notes section. Please be prepared to sign consent for IV therapy. If you apply on calendar you do not have to submit a request form. We will not charge your billing method until completion of therapy. A Same Day Service Fee ($35) is applied with every IV & IM therapy that is requested for same day. An After Hours Fee ($100)  is applied to all requests after 5pm.

Option 2: Request Form

After submission we will pair you with a nurse that’s available in your area. Your nurse will reach out for introduction and consultation. Reserve all medical questions for your nurse when paired. Please include any important medical history in notes section. Please be prepared to sign consent for IV therapy. If you apply on calendar you do not have to submit a request form. We will not charge your billing method until completion of therapy. A Same Day Service Fee ($35) is applied with every IV & IM therapy that is requested for same day.

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